Modern concepts in cervical carcinogenesis

The article discusses modern ideas about cervical carcinogenesis as a multi-stage process of multifactorial genesis. Currently, the pathogenesis cancer (CC) are based not only on understanding role high-risk oncogenic human papillomavirus (HPV) in this and accumulation genetic changes caused by it, but also formation complex HPV interactome, or network intermolecular interactions oncoproteins with host cell proteins. Carcinogenesis involves wide range epigenetic events and, above all, impairment regulatory function miRNAs. An important is attributed to concept stem cells (CSCs) formulated recent years, which closely related explanation disease recurrence treatment resistance, well new approaches treatment. cervicovaginal microbiome microenvironment, responsible for natural clearance HPV, regression epithelial lesions, modeling immune response, becoming promising objects research. aim review was present up-to-date information most mechanisms carcinogenesis, CC, based, particular, use knowledge miRNAs, CSC markers, state microbiota.